The ability that modifies the power and toughness of Enemy of Enlightenment applies only while it's on the battlefield.

If a spell or ability causes an opponent to draw one or more cards, wait until that spell or ability has finished resolving to determine whether Enemy of Enlightenment dies for having 0 toughness. If that spell or ability also causes cards to leave that player's hand, Enemy of Enlightenment may briefly be a 0/0 creature without dying.

As the last ability resolves, first you choose a card in hand without revealing it, then each other player in turn order does the same. Then all the chosen cards are discarded at the same time.

If any player can't discard a card, skip that player and each other player discards a card.